You know how much of iga nephropathy

iga nephropathy (IgA nephropathy), also known as autoimmune kidney disease, is the body to produce anti-microbial antigen IgA antibodies, a large number of IgA and IgA immune complex deposition in the mesangial area, activate the complement pathway, causing disease kidney injury. Appear recurrent gross hematuria or microscopic hematuria may be associated with varying degrees of proteinuria, some patients may appear severe hypertension or renal insufficiency.

For gross hematuria occurred mainly upper respiratory tract infection (gastrointestinal or urinary tract infection) after a few hours to 1-2 days; no more associated symptoms, a small number of urinary discomfort, which was diagnosed as acute cystitis; gross hematuria in children and adolescents (80-90%) than adults (30-40%) more common; nothing to do with the severity of disease; renal pathology typically Lee's grade level Ⅱ ~ Ⅲ.

A large number of proteinuria, proteinuria (+ - ++), with or without microscopic hematuria; with or without microscopic hematuria; some patients with nephrotic syndrome, kidney light microscopy can be: small lesions and mild diffuse proliferative glomerulonephritis; kidney pathology typically Lee's grade level Ⅰ ~ Ⅳ.

50% of patients with elevated serum IgA levels. 37 to 75% of patients measured containing specific IgA circulating immune complexes. Proteinuria quantification and classification of the disease IgA nephropathy judgment, prognosis is very important. Proteinuria <1g / 24 h are often mild and focal mesangial hyperplasia. Moderate to severe proteinuria more diffuse mesangial proliferation, often accompanied by crescents and glomerulosclerosis. Serum creatinine increased to 1.5mg / dl (132.6umol / L) mostly for disease progression. GFR <20ml / min, the pathological changes in the case of Ⅲ level and above. Urine RBC morphology were pleomorphic, suggesting that the source is glomerular hematuria.

iga nephropathy although other kidney disease does not seem as serious, but if you have been delayed, or intermittent treatment, it will aggravate the condition, and then converted into uremia terrible disease.


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