What iga nephritis treatment should pay attention

A large number of proteinuria will lead to a lot of lost plasma protein, causing hypoproteinemia. So, IGA Nephropathy serious? Proteinuria of glomerular, tubular, and this will cause damage, resulting in renal fibrosis. Studies have demonstrated that the incidence of proteinuria is the sole cause of uremia first critical factor, albuminuria greatest harm that drugs eclipse kidneys, causing uremia.

IgA nephropathy with hematuria, with a large number of proteinuria is often overlooked, and renal biopsy diagnosis before treatment misleading. According to clinical statistics, found in the extracted records in iga nephropathy urine protein high as up to 3.0 ~ 4.5 g / 24h, more performance for the nephrotic syndrome. Pathogenesis of IgA nephropathy proteinuria complex, depending glomeruli and (or) in patients with renal tubular injury.

Clinical manifestations of massive proteinuria in IgA nephropathy patients, suggesting that among its tubulointerstitial damage, protect the kidney function is very important. With massive proteinuria as the main clinical manifestations of IgA nephropathy, although it can not be independent from the cause for a group of characteristic cases, but indeed in the clinical manifestations of IgA nephropathy separate records proteinuria, hematuria with respect to its treatment of IgA kidney disease more difficult. Recent studies have demonstrated that IgA nephropathy proteinuria promote progress. Animal model with massive proteinuria, proteinuria regulation of extracellular matrix proteins and the gene encoding TGF-β while increasing kidney protease inhibiting factor expression; between degree of proteinuria and renal interstitial inflammation, monocyte-macrophage cell infiltration related .

Restricted diet of protein intake can reverse glomerular filtration and a ball and a small tube mast, slow decline in glomerular filtration rate. The extracted records in IgA nephropathy proteinuria showed pathological grade heavy damage, renal tubular damage associated with proteinuria; clinical manifestations of serum creatinine, blood urea nitrogen increased. Tip heavy proteinuria may promote progress iga nephropathy.

Common clinical side treatment of urinary protein IgA nephropathy

Therefore, clinicians treating patients with IgA nephropathy massive proteinuria of great importance: First, to strengthen the primary disease treatment, hormone-sensitive hormone therapy can reduce urinary protein excretion; followed diet protein intake, decrease glomerular High filtration and urinary protein excretion; may exercise discretion immunosuppressant drugs, reduce urinary protein, lower blood pressure, slow the progression of kidney function; the long-term is difficult to control iga nephropathy proteinuria, can be repeated if necessary biopsy prognosis .

In short, no matter what causes iga nephropathy, we must take it seriously, because the kidneys important human excretory organ, after suffering from the disease, patients in the treatment must choose a professional regular hospital for kidney disease, and actively prevent disease recurrence.


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