iga nephropathy Lee grading

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(A) iga nephropathy Lee grade level Ⅰ:

Patients with this stage of the vast majority of normal glomerular occasional mild mesangial widening (segments) with and (or) not associated with cell proliferation, tubular and interstitial there is no change, this is the most hierarchical Lee a type of light.

(B) iga nephropathy Lee Ⅱ grade level:

This period is shown patients with glomerular mesangial proliferation and focal sclerosis (<50%), there is a rare small crescent, between tubular and renal interstitial without damage. This issue with respect to the first part of the lesion is severe, the light microscope for the focal lesion, the lesion affected the minority glomeruli (focal) and glomerular portion leaflets (segments).

(C) iga nephropathy Lee grade level Ⅲ:

When patients showed diffuse glomerular mesangial proliferation and broadening (and occasionally focal segmental), occasional small crescent; renal tubular and interstitial changes are showing between focal renal interstitial edema, occasionally cell infiltration, tubular atrophy rare.

Cell infiltration can lead to inflammation, this time to stop if not, in the course of the inflammatory response in renal cell phenotype transformation occurs, and will release a series of induced renal toxicity factor. The area will be increased glomerular sclerosis, tubular atrophy will increase, there will be between renal vascular renal interstitial fibrosis.

(D) IgA nephropathy Lee Ⅳ grade level:

Glomerular lesions showed severe diffuse mesangial proliferation and sclerosis, some or all of glomerulosclerosis, visible crescent (<45%). Tubular atrophy, interstitial infiltration, and occasionally renal interstitial foam cells.

Typing this crescent take an example: this type crescent close to 50%, can be said that if patients do not pay attention, it will most likely achieve this figure, but studies have shown that when the crescent exceeds glomerular When more than 50 percent of the total, is the crescent glomerulonephritis (or crescent iga nephropathy), which is other than domestic lupus nephritis most common type II - immune complex glomerulonephritis crescent, its severity without saying The metaphor.

(V) IgA nephropathy Lee Ⅴ grade level:

Nature glomerular lesions similar level Ⅳ, but more severe glomerular crescent formation> 45%; between tubular and renal interstitial lesions similar level Ⅳ, but more serious.

This disease of IgA nephropathy IgA nephropathy is the most serious, it is also the most difficult to treat, iga nephropathy treatment and Ⅳ stage treatment is no different, but the need for more stringent treatment, perhaps in the treatment time will be relatively long.

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