Causes IgA nephropathy

IgA nephropathy is the cause of a lot of people do not understand, but now more high IgA nephropathy, we must understand, then let our experts to explain it in detail.
The main cause of IgA nephropathy is the following:
1, IgA nephropathy patients abnormal precipitation mainly IgA immune complexes involved in pathogenicity: IgA nephropathy in vivo in patients with glomerular mesangial area of ​​immune complexes precipitated a lot of material, which is mainly IgA immune complexes with IgA nephropathy patients with renal small mesangial cells with high affinity, after a combination of both can lead to kidney inherent cells transformed phenotype and cause disease.
2, kidney mesangial cells in patients with IgA nephropathy IgA involved in the inflammatory response: The IgA nephropathy initial inflammatory reaction, when the disease, renal glomerular mesangial cells in patients with inflammatory damage will be stimulated to produce inflammatory cytokines, leading to a large number of immune complex precipitation in the patient's kidneys and eventually causes the generation of diseases.
3, IgA nephropathy has a genetic predisposition: the pathogenesis of IgA nephropathy patient population to investigate familial aggregation phenomena can occur in patients with IgA nephropathy section, which shows that IgA nephropathy have a genetic predisposition to a certain extent.
The infection is the cause of IgA nephropathy: a cold, tonsillitis, fever appears to the naked eye or occult blood in urine, recurrent infection factors, most patients go to the hospital for medical treatment when urine abnormalities appear in the body.
IgA nephropathy is the cause of what you learned about it? After reading the full text of the introduction to this if you have any questions please feel free to consult our online experts.



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