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IgA nephritis is a special type of glomerulonephritis, children and adolescents are high-risk population of IgA nephritis, IgA nephritis itself is a kind of immune system, do a good job the premise of the treatment of IgA nephritis is to be in the differential diagnosis of patients with IgA nephritis, to carry out the diagnosis of IgA nephritis is very important. The correct diagnosis is helpful to patients with timely treatment.
Differential diagnosis of IgA nephritis:
First, streptococcus infection after acute glomerular nephritis
IgA nephropathy with acute nephritis syndrome should be identified, the former has a long incubation period, the latter has a short incubation period, the condition is repeated, and the combination of laboratory tests (such as ASO, C3) can be distinguished.
Two, thin basement membrane nephropathy
Often in the persistent microscopic hematuria, often had a positive family history of hematuria, renal biopsy showed IgA negative, diffuse glomerular basement membrane thinning. It is not difficult to identify.
Three, secondary IgA deposition mainly of glomerular disease
Allergic purpura nephritis renal pathology and immunopathology and IgA nephropathy is the same, but the former is often typical of renal performance, such as skin purpura, joint swelling, pain, abdominal pain and melena and can be identified.
Chronic alcoholic cirrhosis 50% ~ 90% alcohol cirrhosis patients with renal tissue in IgA immunoglobulin deposition, but only a small number of patients with the clinical manifestations of renal involvement. The identification of IgA nephropathy is mainly based on the presence of cirrhosis.
Lupus nephritis were all bright immunofluorescence (IgG, IgA, IgM, C3, C1q and fibrinogen related antigen were positive). In addition, the clinical features of systemic lupus erythematosus with multi system involvement and immunological examination are helpful to identify.
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